Home >> Archive >>Vol:1, No:1>>Albumin Adsorption on a Stationary Microparticle

Albumin Adsorption on a Stationary Microparticle

| Mehmet Melih Tatlisoz | | Cetin Canpolat |

Year: 2022 | Vol: 1 | No: 1 | PP 9-27
Abstract
In this study, the behavior of the albumin adsorption mechanism is numerically investigated within a microfluidic chip. The adsorption mechanism is modeled with the classical Langmuir approach, and electrokinetic flow conditions are employed. The spherical adsorbent surface is placed at the center of gravity of the designed microchannel. Adsorption behavior is investigated by varying the external electrical field (E), the diameter of the spherical microparticle (DP), initial protein concentration (Cinit), the existence of another solid boundary in the close proximity of the adsorbent surface, and different geometries of adsorbent surfaces, which are triangular, rhombic and square. Initially, generated numerical code is adopted to a similar experimental study, and the code validation is carried out. Adsorption behavior of the albumin varies with a consistent pattern for the inspected parameters. It is concluded that albumin adsorption can be controlled adequately with a microfluidic chip under proposed operating conditions. Moreover, many kinds of protein species can be controlled with the proposed design because of their analogical nature.

Keywords
Microfluidics; Albumin; Adsorption Phenomenon; Electrokinetics; Mathematical Modelling
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